Journal of research in medical and health sciences
Journal of Research in Medical and Health Sciences (ISSN 3105-5893) is a academic journal dedicated to promoting research advancement and the practical application of achievements in the fields of medicine and health sciences. The journal aims to serve medical and healthcare researchers, clinical physicians, public health experts, and university faculty and students. It focuses on cutting-edge breakthroughs in medicine and innovations in health services, addressing key topics such as basic medicine, clinical medicine, public health, life sciences, and health management. The journal is committed to providing a high-level platform for academic exchange and the sharing of research outcomes in medical and health sciences.
Study on the Characteristics of Traumatic Psychological Reactions and Graded Precision Intervention Strategies in Populations with Accidental Injuries
Accidental injury is a sudden physical injury event. Due to its unpredictability and the suddenness of its harmful consequences, it is extremely easy for the injured to fall into a dual stress state of psychology and physiology. Since the psychological reactions caused by trauma are difficult to cure, they not only directly affect patients' compliance with treatment and the degree of physical rehabilitation, but also exert irreversible adverse effects on the injured's subsequent quality of life and social adaptability. Taking the population with accidental injuries as the research object, this paper sorts out the core types of their traumatic psychological reactions, constructs a scientific and operable three-level evaluation system for traumatic psychological reactions combined with clinical practice, and analyzes the phased and individualized characteristics of such reactions. It further explores the influencing factors at the individual, social and medical levels, conducts empirical analysis by integrating quantitative forms and two typical clinical cases, and then puts forward targeted graded precision intervention strategies. The research aims to realize the coordinated promotion of physical rehabilitation and psychological rehabilitation, and provide practical references for clinical medical treatment and community rehabilitation work.
populations with accidental injuries; traumatic psychological reactions; graded evaluation; precision psychological intervention; psychological rehabilitation
Copyright (c) 2026 Journal of research in medical and health sciences https://creativecommons.org/licenses/by-nc/4.0
Reinterpretation of the Educational Psychology Connotation of Vygotsky's Theory of the Proximal Development Zone
Since Vygotsky's theory of "zone of proximal development" was proposed, it has become one of the most influential concepts in the field of educational psychology. However, in the long-term dissemination and application, the theory tends to be simplified to the operation technique of "teaching scaffolding", and its profound philosophical foundation, emotional dimension and methodological implications need to be further explored. This paper aims to reinterpret the connotation of educational psychology of the zone theory of the zone of proximal development. By sorting out its theoretical roots and methodological foundation, this paper first reveals the limitations of the current understanding of this theory. Furthermore, this paper reinterprets it from three dimensions: firstly, based on the perspective of cognitive-social integration of "learning scaffold", the essence of teaching interaction in the nearest development zone is discussed; Secondly, the theory of the nearest development zone is extended to the field of moral education and teacher professional development, and its educational value as a "developmental space" is explained. Finally, this paper summarizes the contemporary enlightenment of the theory of the zone of proximal development, and advocates a return to its methodological integrity as the core component of the "cultural-historical development theory", and provides a more vital theoretical reference.
Vygotsky; nearest development zone; emotional experience; value of education
Functional Positioning and Development Priorities of Township General Practice Medicine in the Primary Healthcare System
Against the backdrop of the continuous advancement of the hierarchical medical system, the in-depth implementation of the Healthy China strategy, and the acceleration of population aging, township general practice medicine has gradually shifted from a reserve force for the diagnosis and treatment of common diseases at the primary level to an important carrier linking basic medical care, public health services, and continuous health management. From the perspective of primary healthcare governance, this paper reviews the background of the formation and functional evolution of township general practice medicine, and analyzes its practical roles in first-contact care, chronic disease follow-up, health management for key populations, bidirectional referral coordination, and the integration of medical treatment and prevention. Based on current practice, it further points out that its development is still constrained by such factors as insufficient talent training and job attractiveness, mismatches between service capacity and residents’ needs, inadequate assessment and incentive mechanisms, and weak information connectivity and data sharing. On this basis, this paper argues that the development of township general practice medicine should not be limited to expanding personnel and service coverage, but should be systematically promoted in terms of improving post competency, optimizing continuity of care, strengthening county-level collaboration, and enhancing institutional and digital empowerment, so as to improve the quality and accessibility of primary healthcare services and better support the implementation of hierarchical diagnosis and treatment as well as the realization of national health goals.
township general practice medicine; primary healthcare services; hierarchical diagnosis and treatment; chronic disease management; primary healthcare governance
Analysis of Acupuncture and Moxibustion in the Treatment of Facial Nerve Inflammation
Objective: This article analyzes the acupuncture treatment process of patients with facial neuritis, and explores the role and advantages of acupuncture in the treatment of facial neuritis. Methods: The report describes patients with facial nerve inflammation and presents the results of acupuncture treatment. The treatment process and effects are also analyzed. Results: After 4 weeks of acupuncture treatment, the patient's facial nerve function significantly improved and their quality of life also enhanced. Conclusion: Acupuncture treatment is one of the effective methods for treating facial nerve inflammation and is worthy of being widely applied in clinical practice.
acupuncture; facial neuritis; case analysis
Pathogenic Role of Histone Deacetylase SIRT6 in Dyskeratosis Congenita by Regulating Telomere Length Maintenance Mechanism
Dyskeratosis congenita is a rare hereditary syndrome characterized by structural and functional abnormalities of telomeres. Clinically, it mainly manifests as premature aging of multiple tissues and organs, hematopoietic failure, and high incidence of malignant tumors. Current studies mostly focus on mutation screening of telomerase-coding genes, while the exploration of mechanisms by which epigenetic modifications participate in the occurrence and progression of the disease remains insufficient. As a highly specific histone deacetylase, SIRT6 plays an irreplaceable role in chromatin conformation stability, DNA damage repair and telomere structure maintenance. However, its expression profile, regulatory pattern and functional value in the pathological process of dyskeratosis congenita have not been systematically elucidated. In this study, telomere dysfunctional cells were used as an in vitro model to detect the transcription and translation levels of SIRT6, and to analyze the intrinsic correlation between its expression and relative telomere length. SIRT6 expression was intervened by gene silencing and overexpression techniques to observe its effects on cell proliferation, apoptosis and the expression of telomere-related proteins, and to explore the molecular pathway of SIRT6 in regulating telomere length maintenance. The results showed that SIRT6 expression was significantly decreased in dyskeratosis congenita model cells and was positively correlated with the degree of telomere shortening. Inhibition of SIRT6 further aggravated telomere attrition and cellular dysfunction, while upregulation of SIRT6 partially restored telomere structural stability and ameliorated pathological cellular phenotypes. SIRT6 maintains telomere length homeostasis and delays cellular senescence mainly through deacetylation of histones in telomere regions, optimizing chromatin compaction and enhancing the binding efficiency of telomere protective proteins. This study enriches the pathogenic mechanism of dyskeratosis congenita from the perspective of epigenetic regulation, and identifies SIRT6 as a potential intervention target for this disease.
SIRT6; Histone deacetylation; Telomere homeostasis; Dyskeratosis congenita; Epigenetics; Drug target
Gene Editing Reshaping Medicine: Precision Applications, Technical Challenges, and Ethical Breakthroughs
As a revolutionary breakthrough in the field of life sciences, gene editing technology is profoundly reshaping the landscape of medical and pharmaceutical research. This paper systematically explains the molecular mechanisms of gene editing technology, with a particular focus on its application value in core areas such as the construction of precise disease models, the development of innovative gene therapies, targeted drug discovery, and xenotransplantation. It also deepens the analysis of these application scenarios in light of the latest clinical research findings from 2024 to 2025. At the same time, the paper thoroughly explores key challenges in the application of this technology, including off-target effects, immunogenicity, and ethical controversies. It further reviews in detail the current progress in technological optimization strategies and the development of ethical regulatory systems, and proposes future pathways for the coordinated advancement of technological innovation and ethical governance, with the aim of providing more comprehensive theoretical support and practical guidance for the standardized clinical translation of gene editing technology.
Gene editing technology; Medical and pharmaceutical research; Gene therapy; Disease models; Drug development; Precision medicine; Xenotransplantation; Ethical regulation
Integrative Theoretical Mechanism of Dance Education in Regulating the Adolescent Neuro-Endocrine-Immune Network
The paper constructs an integrative biopsychological theoretical framework for dance education promoting adolescent physical and mental health. The research proposes that dance, integrating the three attributes of rhythmic movement, emotional expression, and social interaction, serves as an "ideal perturbation source" for regulating the neuro-endocrine-immune network. Its core mechanism lies in achieving a paradigm shift from "stress reduction" to "growth promotion," simultaneously inhibiting excessive stress-immunosuppression pathways and activating growth-immunoenhancement pathways. Theoretical deduction indicates that dance optimizes autonomic nervous system balance, shapes an internal environment supportive of positive emotions and neural plasticity, and enhances immune homeostasis via psychoneuroimmunological pathways. Dance also proactively reconstructs positive emotions through body postures and strengthens the neural foundations of self-efficacy and social belonging. Ultimately, a "Body-Mind Resonance Spiral" model is formed, elucidating how physiological optimization and psychological experiences mutually promote each other, creating a positive feedback loop. This study demonstrates the fundamental constructive value of dance education in adolescent development, providing an interdisciplinary explanation for the public health significance of arts education.
Adolescent development; Neuro-endocrine-immune network; Psychoneuroimmunology
The Interaction Mechanism and Application Research of Psychological Judgment and Self-Redemption
With increasingly intense social competition and an accelerating pace of life, individual mental health issues have gradually garnered public attention. This study explores in detail the intrinsic connection and interaction mechanism between psychological judgment and self-redemption, providing an integrated theoretical perspective for understanding the psychological adjustment mechanisms of individuals in adversity. Psychological judgment, as the cornerstone of individual cognition and emotional responses, permeates and profoundly influences the entire process of self-redemption. Accurate psychological judgment helps individuals more precisely identify the core of problems and fosters proactive problem-solving behaviors, thereby facilitating the process of self-redemption. Conversely, erroneous psychological judgment may lead individuals into cognitive biases and emotional distress, thereby hindering their psychological adaptation, development, and self-redemption. Meanwhile, reflection and summarization during the self-redemption process also prompt individuals to revise their psychological judgment methods, forming a virtuous cycle. Through theoretical analysis, combined with empirical research and case studies, this study reveals the complex interaction between psychological judgment and self-redemption. In practical applications, this paper proposes the application of psychological judgment and self-redemption theories in fields such as personal growth, psychological intervention, and organizational management, providing an effective approach to maintaining and improving individual mental health.
Psychological judgment; Self-redemption; Mental health; Cognitive process; Practical application
Analysis of the Treatment of Periarthritis of Shoulder with Fire Needle Combined with Cupping Therapy
Objective: This article explores the clinical efficacy of the combined therapy of fire needle and cupping in the treatment of periarthritis of the shoulder by analyzing the treatment process of patients with periarthritis of the shoulder who received this therapy. Methods:A combined therapy of fire needling and cupping was applied to patients with shoulder periarthritis, and the treatment process and effects were analyzed. Results:After 4 weeks of treatment, the patient's shoulder and joint pain significantly reduced, the range of motion improved significantly, and the quality of life improved as well. Conclusion:The combination therapy of fire needling and cupping is currently a highly recommended treatment method in clinical practice. It is effective for shoulder periarthritis and can significantly alleviate pain and improve the mobility of the shoulder joint.
Ignipuncture; Cupping; Scapulohumeral periarthritis; Activity functions
Exploration of Teaching Reform in the Comprehensive Nursing Skills Training Course Based on Outcome-Based Education
Against the backdrop of rapid development of medical technology and diversified patient needs, nursing education is facing innovative challenges. Traditional nursing training mainly relies on one-way knowledge transmission and mechanical operation training, which leads to insufficient clinical thinking, self-learning, and adaptability to complex situations among students. Based on the Outcome Based Education (OBE) concept, this study systematically reconstructs the nursing comprehensive skills training course and proposes a modular curriculum design framework guided by core clinical competencies, covering modules such as basic nursing operations, specialized nursing skills, and emergency treatment. Through multiple methods such as situational simulation, layered teaching, and problem-based learning (PBL), students' clinical decision-making and teamwork abilities are strengthened. A three-dimensional dynamic evaluation system including skill operation, clinical thinking, and professional ethics has been constructed, and a combination of formative evaluation and summative evaluation is adopted to track the development trajectory of students' abilities in real time.The study verified the effectiveness of the reform through empirical analysis: the experimental group's students' skill operation qualification rate increased by 23.6% compared to the traditional teaching group, the excellent rate of clinical thinking assessment increased by 18.4%, and the satisfaction rate of graduates' job competence reached 92%. Teaching feedback shows that 87.8% of students believe that practical training projects are closer to clinical practice, and 92.1% recognize the teaching value of virtual simulation platforms. Compared with traditional models, the reform curriculum has shown significant advantages in goal setting, innovative methods, and scientific evaluation, effectively shortening students' clinical adaptation period and improving the efficiency of teaching resource utilization. The study also pointed out that the current reform needs to further optimize the layered teaching strategy, strengthen interdisciplinary scenario simulation training, and establish a dynamic feedback mechanism based on big data. This study provides a replicable practical paradigm for the reform of nursing training courses, emphasizing the need for outcome oriented teaching design to closely connect with clinical needs, and promoting knowledge transfer and ability transformation through diversified teaching methods and evaluation systems. Future research will expand the sample range, explore the application of artificial intelligence and virtual reality technology in skill training, build intelligent and personalized training support systems, and promote the development of nursing education towards precision and sustainability.
Outcome oriented education; Nursing comprehensive skills training; Curriculum and teaching reform
Treatment of Postherpetic Neuralgia with Acupuncture at Jiaji (EX-B2) Points Combined with Moxibustion Using Moxa Cones
Objective: To analyze the treatment process of a patient with postherpetic neuralgia and explore the advantages of acupuncture at Jiaji (EX-B2) points combined with moxibustion using moxa cones in the treatment of postherpetic neuralgia. Methods: One case of postherpetic neuralgia was reported. The patient was treated with acupuncture at Jiaji (EX-B2) points combined with moxibustion using moxa cones, and the therapeutic outcome was analyzed and discussed. Results: After 4 weeks of treatment, the patient’s pain was markedly relieved and sleep returned to normal. Conclusion: Acupuncture at Jiaji (EX-B2) points combined with moxibustion using moxa cones showed a significant therapeutic effect in the treatment of postherpetic neuralgia and is worthy of clinical promotion. More importantly, treatment should be initiated as early as possible at the onset of the disease so as to actively prevent the occurrence of postherpetic neuralgia.
Postherpetic neuralgia; Jiaji (EX-B2) points; Moxa-cone moxibustion
Mechanisms and Research Progress of Stem Cells in Tissue Repair and Aging Intervention
The accelerating aging population has made age-related degenerative diseases and impaired tissue repair major public health concerns. Owing to their capacities for self-renewal, multilineage differentiation, and immunomodulation, stem cells have demonstrated significant potential in tissue regeneration and aging intervention. In recent years, mesenchymal stem cells, induced pluripotent stem cells, and their derived exosomes have achieved substantial experimental and clinical progress in the repair of bone, skin, myocardial, and nervous system injuries. Their therapeutic effects are mainly associated with paracrine regulation, remodeling of the immune microenvironment, promotion of angiogenesis, suppression of oxidative stress, and improvement of mitochondrial function, showing potential value in delaying cellular senescence phenotypes and alleviating age-related functional decline. This paper reviews the key mechanisms by which stem cells contribute to tissue repair and aging intervention, summarizes recent research progress, and further analyzes challenges in clinical translation, including safety risks, ethical controversies, and standardized preparation, with the aim of providing references for optimizing strategies in regenerative medicine and anti-aging interventions.
stem cells; tissue repair; aging intervention; regenerative medicine; exosomes
Application of Augmented Reality Technology in Traditional Chinese Medicine Education and Clinical Practice
With the continuous development of digital healthcare and intelligent technologies, augmented reality has gradually entered the fields of medical education and clinical practice, offering new possibilities for the presentation of traditional medical knowledge and diagnostic models. Traditional Chinese medicine features a highly integrated and experience based theoretical system, knowledge structure, and practical framework. Its teaching and clinical processes rely heavily on spatial perception, dynamic understanding, and procedural demonstration, while conventional instructional and practical approaches remain limited in terms of intuitiveness and interactivity. By superimposing virtual information onto real environments, augmented reality technology enables the visual representation of meridian pathways, visceral structures, diagnostic procedures, and operational key points, thereby providing technical support for Traditional Chinese Medicine education and clinical practice. On the basis of outlining the fundamental characteristics of augmented reality technology, this paper systematically analyzes its major application forms and implementation pathways in Traditional Chinese Medicine education and clinical practice, and discusses its potential value in improving teaching effectiveness, supporting clinical operations, and promoting the modernization of Traditional Chinese Medicine. In addition, by drawing on existing studies and application cases, the challenges associated with the promotion of augmented reality technology in the field of Traditional Chinese Medicine are examined from technical, cognitive, and practical perspectives, with the aim of providing references for future research and practice.
Augmented reality technology; Traditional Chinese Medicine education; Clinical practice; Digital healthcare; Medical education
Research Progress on the Biological Characteristics, Detection Technologies, and Clinical Applications of Tumor Markers
Tumor biological markers are characteristic bioactive substances that are either directly synthesized and secreted by abnormally proliferating tumor cells or released by the host in response to oncogenic biological behaviors during the initiation and progression of malignant tumors. These markers play an irreplaceable role in critical clinical scenarios such as cancer screening, therapeutic efficacy evaluation, and prognosis prediction. This article systematically reviews the biological characteristics, classification systems, and latest advances in detection technologies of tumor markers, with emphasis on their performance limits and clinical bottlenecks in early cancer screening. Furthermore, it analyzes emerging trends in the integration of multimodal detection technologies, providing a theoretical reference for precision oncology practice.
Sharing, Precision, and Empowerment: Based on the Provincial Digital Intelligence LibraryResearch on the Construction of Reading Therapy Support System for Poor College Students through Inter-Library Mutual Assistance
Against the backdrop of the popularization and digital transformation of higher education, the economic pressure and psychological development needs faced by the impoverished student group in colleges and universities are intertwined, becoming an important issue affecting educational equity and the quality of talent cultivation. Reading therapy, as an economical, safe and profoundly influential psychological aid, is increasingly highlighting its value. However, a single university library has limitations in terms of resource reserves and professional service capabilities, making it difficult to implement large-scale, personalized and continuous reading intervention for impoverished students. This research takes "sharing, precision and empowerment" as its core concepts, aiming to explore how to rely on the inter-library mutual assistance mechanism of digital and intelligent libraries in universities within the province to build a systematic, collaborative and intelligent reading therapy support system for impoverished students in universities. The article first analyzes the current situation and predicament of reading therapy services carried out by university libraries at present, especially those for students from poor families. Secondly, it expounds the necessity and feasibility of combining digital intelligence technology with inter-library mutual assistance. Furthermore, from four dimensions: the resource layer, the platform layer, the service layer, and the mechanism layer, the theoretical model and implementation framework of this support system were constructed in detail, and a closed-loop service process including precise demand identification, intelligent resource matching, dynamic process intervention, and scientific effect evaluation was designed. Finally, the guarantee strategies and future prospects for the implementation of the system were proposed, with the aim of providing theoretical references and practical paths for promoting educational equity, enhancing the accuracy and effectiveness of psychological education in colleges and universities, and driving the intelligent transformation and service innovation of libraries. This study contains an explanatory table on the "core components and functions of the support system".
Poor students in colleges and universities
Exploration of the Path of Mental Health Education for Left-behind Children in Rural Areas under the Coordinated Mechanism
This study focuses on mental health education for rural left-behind children, analyzing typical psychological issues such as emotional deficits caused by parent-child separation, behavioral deviations resulting from excessive grandparents' indulgence, and inappropriate behaviors stemming from estranged parent-child relationships. Given the challenges in rural mental health education—including teacher shortages, marginalized curricula, and difficulties in interdisciplinary integration—the study proposes establishing a comprehensive intervention framework characterized by "government leadership, school-centered initiatives, family participation, and social collaboration." Government departments should dismantle household registration barriers to ensure school enrollment rights for migrant children while increasing funding for mental health services. Schools should implement dynamic psychological record management systems and develop personalized activity plans for targeted interventions. Parents are encouraged to enhance emotional communication and refine educational approaches. Society should coordinate resources to build a comprehensive support system. Only through multi-stakeholder collaboration mechanisms can the mental health status of rural left-behind children be significantly improved, creating a more favorable environment for their growth.
Application and Reflection of Comprehensive Geriatric Assessment in retired cadres
Objective: To systematically analyze the application status, practical value and existing problems of comprehensive geriatric assessment (CGA) in the health management of retired cadres in the cadre rest homes, so as to provide theoretical basis and practical reference for improving the quality of full-cycle health care for the retired army population.Methods:The domestic CGA related research literature, health management policies and practice cases of cadre rest homes were retrieved, and the evaluation content, application effectiveness, and existing difficulties were systematically sorted out and analyzed from the perspective of the characteristics of service objects of cadre rest homes, so as to put forward targeted improvement strategies.Results:CGA has been gradually introduced as a core tool of health management for the elderly, and significant results have been achieved in the comprehensive management of chronic diseases.However, there are still some problems, such as insufficient standardization, insufficient professional ability of the staff in the cadre rest institutions, and insufficient awareness of CGA among the evaluation objects. Conclusion:It is necessary to improve the standardized assessment system, build a diversified team,and popularize CGA knowledge to build a CGA application model suitable for the needs of the cadre rest, so as to provide accurate, full-dimensional and continuous health services for the retired cadres,and help the implementation of the"Healthy China" and "Healthy Army" strategy.
The Core Application and Practical Value of Mendelian Randomisation in Drug Target Research
Mendelian randomisatio (MR) has demonstrated critical practical value in drug target research as a causal inference tool leveraging genetic variation. By employing genetic variation as an instrumental variable to simulate randomised controlled trials, MR circumvents confounding factors and reverse causality issues inherent in traditional observational studies, providing low-cost, highly reliable evidence for drug target development. This systematic review examines the current application of MR across three core domains: drug target identification and validation, drug repurposing, and safety assessment. Through exemplary cases in cardiovascular disease, metabolic disorders, and neurodegenerative diseases, it elucidates MR's mechanisms and practical outcomes in screening potential drug targets, expanding indications for existing drugs, and providing early warnings of drug safety risks. Concurrently, it analyses MR's unique advantages and challenges within these core applications, offering methodological guidance for future research. By 2025, MR had facilitated the validation of 18 drug targets progressing to Phase II/III clinical trials and driven the expansion of new indications for three classes of existing drugs, significantly enhancing clinical development success rates. This review aims to provide drug development practitioners with a comprehensive overview of MR's core applications, highlighting its pivotal role as a bridge between fundamental research and clinical translation.
Analysis of Changes in Inflammatory Factor Levels and Pregnancy Rate in the Treatment of Endometritis with Guizhi Fuling Decoction Combined with Metronidazole
Objective This study aims to investigate the impact of Guizhi Fuling Decoction combined with metronidazole on the level of the inflammatory factor CD138 in the treatment of endometritis and its improvement effect on the pregnancy rate. Methods A total of 50 patients with endometritis treated from March 2020 to March 2022 were selected and divided into an experimental group (treated with Guizhi Fuling Decoction combined with metronidazole) and a control group (treated with metronidazole alone) according to the treatment plan. The changes in the inflammatory factor CD138 before and after treatment were detected, and the improvement in the pregnancy rate was analyzed. Results The level of the inflammatory factor CD138 in the combined treatment group significantly decreased, and the pregnancy rate was significantly higher than that in the control group. Conclusion The treatment of endometritis with Guizhi Fuling Decoction combined with metronidazole can effectively reduce the CD138 level and improve the pregnancy rate of patients, which is worthy of clinical promotion.
Linkae Analysis of Textile Finished Products, Pharmaceutical Products, and Health Sectors from the Perspective of Organizational Economics
Based on the input-output analysis theory from the perspective of organizational economics, this study utilizes direct consumption coefficient matrices, total consumption coefficient matrices, and the Leontief inverse matrix to analyze the economic linkages among the textile finished products, pharmaceutical products, and health sectors. The results indicate that the pharmaceutical products sector exhibits significant "core-driven" and self-reinforcing characteristics, forming a deeply symbiotic relationship with the health sector. In contrast, the textile finished products sector demonstrates a "marginal supporting" role with relatively weak linkages. The study proposes that promoting the transformation of the textile sector into high-value-added fields such as medical textiles can foster synergistic development among the three sectors, providing a basis for optimizing industrial policies and enhancing supply chain resilience.
Copyright (c) 2025 Journal of research in medical and health sciences https://creativecommons.org/licenses/by-nc/4.0
Artificial Intelligence in New Drug Development: Current Applications and Future Prospects
To systematically evaluate the current applications, key technologies, and implementation outcomes of artificial intelligence (AI) across the entire drug development process, analyze existing challenges, and explore future directions. Methods: Literature published between 2020 and 2025 was retrieved from core databases including PubMed, MEDLINE, Embase, and the Cochrane Library, focusing on AI applications in target identification, compound design, preclinical research, and clinical trials. A systematic review approach was adopted to summarize implementation pathways, performance metrics, and comparative results versus traditional methods. Results: Over 80 eligible studies were included. Findings indicate that AI demonstrates significant advantages at all stages of drug development: in target identification, AI improved efficiency by approximately 40%–60%; in compound design, generative models reduced lead compound discovery time to one-third to one-half of the original duration; in clinical trials, AI-assisted patient stratification increased recruitment efficiency by about 30%–50%. Additionally, AI models achieved 85%–92% accuracy in predicting drug toxicity and pharmacokinetic parameters, markedly outperforming conventional computational methods. Conclusion: AI is profoundly transforming the paradigm of drug development, leveraging data-driven approaches to substantially enhance efficiency, reduce costs, and improve success rates. Despite challenges in data quality, algorithm interpretability, and regulatory compliance, ongoing technological innovation and multidisciplinary integration are expected to drive drug development into a more precise and efficient era.
Cancer-Related Sarcopenia: Mechanisms, Management, and Future Directions
The deterioration of skeletal muscle mass and function, termed sarcopenia, is a common metabolic comorbidity in oncology. Contemporary understanding frames its etiology as a multifaceted process driven by tumor-host interactions, extending beyond traditional causes like malnutrition or sedentariness. Malignancies facilitate muscle depletion through the systemic release of inflammatory mediators, dysregulation of protein turnover, and alterations in endocrine function. The resultant sarcopenia subsequently diminishes host immunity and increases the therapeutic burden, creating a challenging clinical feedback loop. This systematic review aims to delineate the epidemiology, pathophysiological mechanisms, and clinical relevance of cancer-related sarcopenia, while also summarizing current and potential future management strategies within a multidisciplinary paradigm.
The Relationship Between the Intensity of Short Video Platform Uses and the Development of Adolescents' Self-Identity——Research on the Mediating Role of Psychological Resilience
Short video platforms have been deeply integrated into the daily life of adolescents and have become the core tool for their information acquisition and leisure and entertainment, and their use intensity has a profound impact on the development of adolescents' self-identity during the critical period. This study focuses on the relationship between the intensity of short video platform use and adolescents' self-identity and focuses on verifying the mediating role of psychological resilience. The study found that the use of short videos with excessive intensity will impact the clarity and stability of self-identity through social comparison, information overload, and crowding out offline exploration time, which can easily lead to identity diffusion or premature closure. As a positive personal trait, psychological resilience not only plays the role of a "buffer" to alleviate negative effects but also acts as a "conductor" to affect the internal mechanism of action, that is, high-intensity use will consume psychological resources, reduce psychological resilience, and then hinder the formation of healthy self-identity. The research provides directions for families, schools, and society to formulate educational intervention strategies to help adolescents achieve active self-exploration and identity integration in the digital age.
The Impact of Junior High School Students' Academic Stress on Pathological Gaming Behavior: A Sequential Mediation Model of Emotional Regulation Difficulties and Escape Motivation
With the proliferation of digital media, pathological gaming behavior among junior high school students has become a growing social concern. From the perspective of academic stress, this study explores its relationship with pathological gaming behavior, with a specific focus on the sequential mediating roles of emotional regulation difficulties and escape motivation. A questionnaire survey was conducted among 650 junior high school students using the Academic Stress Scale, Difficulties in Emotion Regulation Scale, Gaming Escape Motivation Scale, and Pathological Gaming Behavior Scale. The results indicated that: (1) Academic stress, emotional regulation difficulties, escape motivation, and pathological gaming behavior were all significantly positively correlated with each other. (2) Academic stress could not only directly predict pathological gaming behavior but also influence it through three indirect pathways: the separate mediating effect of emotional regulation difficulties, the separate mediating effect of escape motivation, and the sequential mediating effect of emotional regulation difficulties → escape motivation. This study constructs a sequential mediation model, revealing the influencing pathway of "academic stress → emotional regulation difficulties → escape motivation → pathological gaming behavior," providing a theoretical basis and practical insights for understanding and intervening in excessive gaming among junior high school students.
Research on Library Bibliotherapy Services for Addressing Inferiority Complex Among Economically Disadvantaged Students in Western Chinese Universities
This paper addresses the issue of inferiority complex among economically disadvantaged students in Western Chinese universities, exploring intervention strategies and practical pathways for library bibliotherapy services. By analyzing the characteristics and causes of this inferiority complex, and integrating the theoretical foundations and mechanisms of bibliotherapy, a library bibliotherapy service framework based on the three dimensions of "Needs—Resources—Assessment" is designed. Corresponding implementation safeguards are also proposed, aiming to provide references for constructing an effective psychological support system within Western Chinese university libraries.
Comparative analysis of high-risk HPV and TCT results in 193 postmenopausal women
Objective, To explore the infection status of high-risk human papillomavirus (HR-HPV) in postmenopausal women and the value of liquid-based thin-layer cytology test (TCT) in cervical lesion screening. Methods: A retrospective analysis was conducted on the HR-HPV and TCT results of 193 postmenopausal women aged 55 and above who underwent colposcopy at Luancheng People's Hospital in Shijiazhuang from 2018 to 2023. Biopsy results were used as the gold standard to calculate and compare the screening efficacy of the two methods. Results: Among the 193 women, 162 were TCT positive, with a positive rate of 83.94%; 107 were HR-HPV positive, with a positive rate of 55.44%. The HR-HPV positive rate was significantly lower than that of TCT （χ² = 109.003, P < 0.001）. Among the 108 biopsy-positive patients, TCT detected 97 cases, with a sensitivity of 89.81%; HR-HPV detected 78 cases, with a sensitivity of 72.22%. In the TCT-negative group, 11 cases of pathological positivity were detected, with a missed diagnosis rate of 10.19%; in the HR-HPV-negative group, 30 cases of pathological positivity were detected, with a missed diagnosis rate of 27.78%. Conclusion: In cervical cancer screening for postmenopausal women, TCT has a high sensitivity and low missed diagnosis rate, while HR-HPV has a relatively low sensitivity and high missed diagnosis rate. The combined screening strategy of HR-HPV and TCT can improve the detection rate of cervical lesions and is an ideal cervical screening model for postmenopausal women.
Academic Procrastination and Smartphone Addiction: A Dual “Inhibition–Substitution” Pathway and a Contextual Framework of “Rhythm–Restraint–Support”
In today’s mobile, high-temptation environment, academic procrastination and smartphone addiction among university students are not isolated phenomena; rather, they co-evolve under the tension between immediate rewards and delayed returns. On the basis of clarifying conceptual boundaries—defining smartphone addiction as the co-occurrence of loss of control, excessive use, and functional impairment, and defining academic procrastination as non-necessary delay accompanied by negative affect—this paper proposes an integrative framework centered on self-control. First, self-control operates via an inhibition pathway that reduces passive distractions and in-the-moment unlocking, and a substitution pathway that offers low-cost strategies for emotion and attention regulation, thereby interrupting the cycle of “anxiety → scrolling → greater anxiety.” Second, behavior emerges from the joint shaping of motivation–incentive–context: weak intrinsic motivation amplifies the substitutive pull of the phone; algorithmic recommendation increases temptation density; and loose learning structures raise the cost of self-regulation. Third, the paper advances context-sensitive interventions and actionable scaffolds under a “rhythm–restraint–support” framework—using implementation intentions and proximal, specific sub-goals to translate long-term aims into executable schedules, and employing fixed deep-work blocks, minimal device accessibility, and process-oriented assessment to lower choice costs and create positive feedback. The contribution lies in translating self-control from an abstract “willpower” notion into a designable and assessable system of action, offering practicable pathways for university curricula and learning support, and laying out structured propositions and operational indicators for subsequent quantitative testing and contextualized practice.
Copyright (c) 2025 Journal of research in medical and health sciences
Invisible Barriers and Socio-Psychological Adaptation of Rural College Students in Urban Development under Urban–Rural Disparities
Against the backdrop of China’s dual urban–rural structure, this study conducts an in-depth analysis of the multidimensional inequities that rural college students encounter during urban employment and career development. The findings indicate that even when holding equivalent—or superior—educational credentials and academic performance, graduates from rural backgrounds remain systematically disadvantaged in urban labor markets due to factors such as information vacuums, weak social networks, cognitive path dependence, deficits in cultural capital, and institutional barriers. These inequalities are manifested not only in job access and compensation, but also—more profoundly—in career trajectories, opportunities for social mobility, and difficulties in urban integration. The paper proposes a multidimensional analytical framework for understanding developmental barriers faced by rural college students in cities, and advances policy, educational, societal, and individual-level strategies to mitigate these constraints.
Multidimensional analysis of social responsibility among nursing college students: from the perspective of educational environment and personal traits
This article studied the social responsibility level and influencing factors of 602 nursing college students in a three-year vocational college in Quanzhou, Fujian Province. By collecting data through a structured questionnaire and using independent t-test, analysis of variance, Pearson correlation coefficient, and multiple regression analysis, it was found that social responsibility is significantly positively correlated with professional satisfaction, nursing professionalism, and sociality. Factors such as grade level and volunteer service experience also affect social responsibility. The study provides data support for nursing education and suggests improving the social responsibility of nursing students through optimizing courses and enhancing practice.
Practice and Exploration of Hospital Informatization Driven by Data as a Production Factor
With the deepening development of the digital economy, data as a production factor has become a core driver of industrial transformation and upgrading. As a key link in the healthcare sector’s digital transformation, hospital informatization still faces challenges such as insufficient data value extraction and weak security safeguards. Guided by practical needs and drawing on theories of data-element activation and the protection of critical information infrastructure, this paper analyzes current gaps in hospitals’ data management, system security, and service efficiency. It then proposes a data-element-centered pathway for informatization that includes building a standardized data system, strengthening information security defenses, and creating smart-healthcare service scenarios. Through practical exploration, the goal is to enhance hospital operational efficiency and the quality of medical services, providing a reference for the high-quality development of healthcare in the context of the digital economy.